Formulation design and optimization of fast dissolving clonazepam tablets by sublimation method
نویسندگان
چکیده
منابع مشابه
Formulation Design and Optimization of Fast Dissolving Clonazepam Tablets by Sublimation Method
Fast dissolving tablets of clonazepam were prepared by sublimation method with a view to enhance patient compliance. A 3(2) full factorial design was applied to investigate the combined effect of two formulation variables: amount of croscarmellose sodium and camphor. Croscarmellose sodium (2-8% w/w) was used as superdisintegrant and camphor (20-40% w/w) was used as subliming agent, to increase ...
متن کاملFormulation Design and Optimization of Fast Dissolving Clonazepam Tablets
Fast dissolving tablets of clonazepam were prepared by direct compression method with a view to enhance patient compliance. A 3(2) full factorial design was applied to investigate the combined effect of two formulation variables: amount of crospovidone and microcrystalline cellulose. Crospovidone (2-8% w/w) was used as superdisintegrant and microcrystalline cellulose (20-40% w/w) was used as di...
متن کاملFormulation Design and Optimization of Fast Dissolving Effervescent Tablets of Clonazepam
tablet formulation (t 16.4 min). Short-term stability studies on the formulation indicated that there are no significant changes in drug 50% content and in vitro dispersion time (p<0.05).
متن کاملDesign and Evaluation of Fast Dissolving Tablets of Clonazepam
In the present work, fast dissolving tablets of clonazepam were prepared by direct compression method with a view to enhance patient compliance. Three super-disintegrants, viz., crospovidone, croscarmellose sodium and sodium starch glycolate in different ratios with microcrystalline cellulose (Avicel PH-102) along with directly compressible mannitol (Pearlitol SD 200) to enhance mouth feel. The...
متن کاملFormulation and Evaluation of Fast Dissolving Tablets of Flunarizine HCl by Sublimation Method Using Treated Agar As Superdisintegrant
In the present work, Flunarizine hydrochloride, an anti-migraine drug has been formulated into fast dissolving tablets by sublimation method using camphor and menthol as sublimating agents and treated agar as superdisintegrant. Concentrations of the sublimating agents were varied keeping the concentration of superdisintegrant fixed. The aim of the study was to prepare fast dissolving tablets wi...
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ژورنال
عنوان ژورنال: Indian Journal of Pharmaceutical Sciences
سال: 2011
ISSN: 0250-474X
DOI: 10.4103/0250-474x.98984